Apple WWDC 2013: 8 things to expect

Apple WWDC 2013: 8 things to expect

Apple's annual Worldwide Developers Conference (WWDC) is a four-day event where programmers socialize and learn to write better iOS and OS X apps. For Apple, however, the WWDC is also a media event, a stage for unveiling new products and services. For instance, the iPhone 4, iOS 6 and the MacBook Pro with Retina Display all debuted at the WWDC.

This year's event, which takes place June 10-14 in San Francisco, will feature new products too. So what can we expect? Probably new and improved Apple software and services -- WWDC is a developer show, after all -- but don't be surprised if there's a last-minute surprise (hint: see the next page).

Click to read the rest of this story on InformationWeek.

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Sensor network designs win IoT contest

Sensor network designs win IoT contest

SAN JOSE, Calif. –A wireless door lock sensor, a universal LED driver for streetlights and an energy-harvesting current sensor were winners in a contest geared to promote the emerging Internet of Things.

All three winners used IP over 802.15.4 networks. The IPSO Alliance, a trade group promoting Internet Protocol for smart objects, hosted the contest.

First place went to the Energy Harvesting Transformer from Redwire Consulting, a self-powered current sensor that clips to any wire and wirelessly connects to the Internet. A Redwire customer aims to have 1,500 of the devices deployed in 100 buildings by the end of the year to ease the job of monitoring energy use.

The CMD Asset Management system from Colorado Micro Devices took second place. The wireless network includes a door lock sensor that can be added to any deadbolt and a sensor that detects an asset as it moves around a network.

“If this was on the market today, I would purchase it to take advantage of IP enabled home security,” said Geoff Mulligan, chairman of the alliance.

Third place went to a group from Spain’s University of Murcia that developed a universal driver for LED streetlights. The Smart Driver controls LED lights that span a range between 350-700mA and 0-120W. It also provides a platform to connect other sensors.

“The quality of implementation and functionality of the prototype was very impressive,” said Tom Herbst, an IPSO board member.

Related stories:
Photos from the frontier: The Internet of Things

Group pushes Internet Protocol for sensor nets

Wireless sensor network challenges and solutions

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Better screens made of organic light diodes: OLED brings out the shine

Better screens made of organic light diodes: OLED brings out the shine

June 7, 2013 — Screens made of organic light diodes promise unfathomable possibilities. Yet high production costs often prevent their widespread use. A new kind of production saves not only costs, but also improves the radiance of the OLED.

The age of the good old cathode ray tube has long since passed. According to the German Federal Statistics Office, by 2011, almost every other German household had a flat screen television. The question, however, is how long our boob tubes -- measuring just a few centimeters thick -- will manage to hold onto the moniker "flat." Rigo Herold of the Fraunhofer Research Institution for Organics, Materials and Electronic Devices COMEDD is already thinking in totally different dimensions in any case: "In 2008, the first manufacturers introduced displays that were less than a millimeter thick." The technology behind these incredibly narrow matt screens is called OLED. The abbreviation stands for "Organic Light Emitting Diode." "OLEDs emit light themselves, and unlike the ordinary liquid crystal display screens of today, they work without background lighting. For this reason, it will soon be possible to manufacture very thin and simultaneously very flexible, bendable displays," explains Herold, who is in charge of "IC and Systems Design" at COMEDD. What you previously knew only from science fiction flicks could also change our everyday viewing experience within the foreseeable future: Screens as thin as paper, applied to clothing, curtains and even windows.

Yet the technology is still in its infancy stages. Beside the minimal lifespan, up to now the extremely high acquisition costs are impeding a widespread breakthrough. "Producing organic light diodes is still very expensive. This is why you still cannot purchase large-scale OLED television screens currently. Right now, the technology is being used primarily for very small screen sizes of just a few square centimeters. Examples include the ViewFinder on digital cameras or -- even smaller -- on cellphone beamers and data glasses," as Herold describes the state of the art. Together with his colleagues, he is researching new production methods for microdisplays.

Subpixels applied directly onto microdisplays

The researchers recently achieved an important breakthrough in this area: Together with VON ARDENNE Anlagentechnik GmbH they are developing a technology for producing mini-OLED screens without color filters. That makes the production process not only cheaper, but even improves the luminosity of the microdisplays. Until now, the color filter suppressed the self-radiance of the OLED, so that only about 20 percent of the emitted light could be used. Two negative effects from the filter sheet being used are responsible for this: First, it suppresses two of the three color ranges of an OLED subpixel; second, as an additional layer applied over the OLED, it automatically dims the generated light.

In order to circumvent the use of the color filter, the red, green and blue subpixels -- which are integral to the depiction of a color image -- must be loaded onto the OLED directly. That was previously impossible. "The subpixels in the tiny display are typically about 8 square micrometers in size. However, conventional technology only allowed for the processing of units greater than 50 square micrometers," says Herold, illustrating the challenge to be mastered. In order to resolve this set of problems, scientists employed a special technology made by VON ARDENNE, their partner company. This technology facilitates the targeted vaporization of organic layers locally, under heat. In this manner, surfaces can be processed that are smaller than 10 square micrometers. "In order to use the technology for OLED microdisplays, we redesigned the entire manufacturing process. It is therefore possible to load the red, green and blue color pixels directly. The use of the color filter is no longer necessary and it is possible to use 100 percent of the light emitted," says Herold.

Smartphones hold up longer

Still, the OLED not only shine brighter, the new production process is also less expensive. Color filters are very expensive to produce. Depending on the application, they have to be custom-designed, consist of suitable materials and be mounted properly. If the filter shifts, for instance, that could have a negative impact on the image quality. "Ultimately, the consumer benefits as well: We all know that our mobile devices, like smartphones and digital cameras, consume a lot of energy each day. The less is used for the color presentation of the displays, the longer our batteries will last for telephone calls, surfing or taking pictures," Herold concludes.

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Stranded orcas hold critical clues for scientists

Stranded orcas hold critical clues for scientists

The study, published recently in the journal Marine Mammal Science, suggests that the data can help scientists better understand the life history of the orca species.

The killer-whale necropsy system was co-developed by Joe Gaydos, director of the SeaDoc Society -- a program of the UC Davis Wildlife Health Center within the School of Veterinary Medicine -- and Stephen Raverty, veterinary pathologist with the British Columbia Ministry of Agriculture.

"Because killer whales are apex predators and flagship conservation species, strandings are sad events," said Gaydos. "But this study confirms that if we make every effort to understand why the strandings occurred, we will ultimately improve the fate of the species."

Gaydos and Raverty developed the standardized killer-whale necropsy system in 2004. The analysis of strandings since then has shown that the protocol, along with increased funding for southern resident killer-whale recovery, has increased the collection of complete data from killer-whale strandings. Traditionally, only one in 50 stranded whale cadavers would be analyzed; now one in three get a full examination.

The increased recovery funding was provided by the U.S. National Marine Fisheries Service and Canadian Department of Fisheries and Oceans.

For the study, researchers analyzed North Pacific killer-whale strandings dating back to 1925. The report noted that while orcas are some of the most widely distributed whales on Earth, very few dead ones are ever found. Over the last two decades, an average of just 10 a year have been discovered stranded across the entire North Pacific Ocean.

"Each stranded orca should be viewed as a unique opportunity to enhance our understanding of this magnificent species," said co-author Raverty.

The study found that 88 percent of all reported killer-whale strandings are fatal, while only 12 percent of the stranded killer whales make it off the beach alive. The dead whales can provide critical clues to the species' overall life history, genetics, and health, as well as the causes of death. With such limited opportunity to do comprehensive sampling and studies, the authors noted the disturbing fact that, until recently, less than 2 percent of dead killer whales were thoroughly examined.

While the study was designed to look at stranding trends and did not evaluate the causes, necropsies on beached orcas have shown that they absorb extremely high loads of humanmade toxins, suffer from infectious diseases and, in the case of fish-eating populations, depend primarily on severely depleted salmon stocks. With the standardized protocol now in place -- providing much more complete data on strandings -- researchers are getting a clearer picture of killer-whale life and death.

"This was a herculean effort to learn more about one of the ocean's top predators," said lead author Michelle Barbieri, a former SeaDoc Society scientist and UC Davis graduate who is currently the lead veterinarian for the National Oceanic and Atmospheric Administration's Hawaiian Monk Seal Research Program.

"We could not have done this without the collaboration of dozens of killer-whale scientists from around the world, who provided stranding and population data from Washington, Oregon, California, Alaska, Hawaii, British Columbia, Mexico, Japan and Russia," she said.

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Magpies make decisions faster when humans look at them

Magpies make decisions faster when humans look at them

June 7, 2013 — Researchers from the Seoul National University found that wild birds appear to "think faster" when humans, and possibly predators in general, are directly looking at them.

"We started this study from our experience" says Dr. Sang-im Lee, the leader of magpie research team and the first author of the paper. "For a long time we had this impression that somehow magpies know that we are watching them because they often fly away from us when we observe them. But when we don't observe them, we can pass them pretty close-by but they don't fly away!"

The finding that animals notice the gaze of humans is not new. Usually animals use gaze of the conspecifics in social contexts and therefore pet animals pay attention to the gaze of humans -- their social mates. Also in the case of predator and prey interactions it is well known that animals such like birds, lizards or deer move away or escape from humans at larger distances when people look directly at them. In these situations it was believed that animals react at larger distance and sooner because the gaze is an indicator to the prey that the predator "wants to catch it." Therefore, when a prey notices the gaze of a predator it moves away from the predator in order to increase safety. Not surprisingly, the researchers found that magpies on the campus of the Seoul National University also flew away at larger distances when humans were directly looking at them.

But this is not the most important finding of this research. When researchers, who were approaching foraging magpies, looked directly at the magpies, the magpies took the decisions faster regardless of whether the final decision was to return to foraging or to fly away and whether the stress or danger perceived by a magpie was low or high. But when the approaching pair of humans did not look at the magpies, the decision to escape or not was taken with a delay. In other words even if the magpies did not perceive the humans as dangerous they still took the decision faster (in this case decision to stay and continue foraging) when the humans were looking at them. This is consistent with the idea that the birds are able to extract more information for their quick decisions from people's faces and/or gaze direction regardless of what kind of information they get. Magpies have lived near humans for centuries or even millenia and such skills might have been important for their survival.

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Gene variant may provide novel therapy for several cancer types

Gene variant may provide novel therapy for several cancer types

This landmark study is published in the June 6, 2013 issue of the journal Science.

Ramon Parsons, MD, PhD, Professor and Chair of Oncological Sciences led the team that discovered a mutation in the tumor suppressor gene PTEN, which has subsequently been recognized as the second most common mutation in cancer, especially in breast, prostate, and brain cancers. PTEN encodes a 403 amino acid lipid phosphatase protein that is critical to cellular growth, proliferation, and survival. Genetic inactivation of PTEN causes tumor development.

In the current study, Dr. Parsons and his team analyzed human cells and discovered a PTEN variant that has an additional protein sequence and is 43 percent longer than normal PTEN. They called this new variant PTEN-Long. Like PTEN, the long form has the same enzymatic activity, but unlike PTEN, it is secreted by the cell and can enter other cells, indicating that the added protein sequence acts as a delivery system for the tumor suppressor gene.

"This study culminates more than a decade of research that began soon after we learned the therapeutic potential of PTEN and the PI3K pathway," said Dr. Parsons. "We are excited about the potential of PTEN-Long as a therapy for multiple cancer types."

Using human breast and brain tumor cells that lacked PTEN and PTEN-Long, the research team introduced and overexpressed PTEN-Long and PTEN into the cells. They found that, similar to PTEN, PTEN-Long decreased the signaling activity on the PI3K pathway, thus reducing cellular proliferation. They also found that PTEN-Long was reduced in breast tumor tissue compared to healthy breast tissue.

To test the therapeutic potential of PTEN-Long, Dr. Parsons and his team injected mice with tumor cells, then administered PTEN-Long or a control preparation to the mice. For one of their tumor models, after five days of treatment, the tumors disappeared completely. The authors conclude that PTEN-Long alters signaling on the PI3K pathway to inhibit tumor growth and that its ability to enter other cells is critical to this process. As insulin operates on the PI3K pathway as well, the research team also noticed a brief increase in glucose concentration in the PTEN-Long treated mice.

"These findings indicate that PTEN-Long may contribute to cell homeostasis and suppression of cancer," said Dr. Parsons. "This gene variant has significant potential as a protein-based therapy to treat cancer, and may have implications in diseases such as diabetes."

Next, Dr. Parsons plans to study the normal functions of PTEN-Long, how tumors become resistant to it, what happens when it is missing, and how it can be used as a tool for therapy.

The work was funded by the NCI, The Octoberwoman Foundation, and the Avon Foundation.

Dr. Parsons is a named inventor of a pending patent filed by Columbia Technology Ventures related to the use of PTEN-Long for the treatment of cancer and may benefit financially from this patent.

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How similar are the gestures of apes and human infants? More than you might suspect

How similar are the gestures of apes and human infants? More than you might suspect

June 6, 2013 — Psychologists who analyzed video footage of a female chimpanzee, a female bonobo and a female human infant in a study to compare different types of gestures at comparable stages of communicative development found remarkable similarities among the three species.

This is the first time such data have been used to compare the development of gestures across species. The chimpanzee and bonobo, formerly called the "pygmy chimpanzee," are the two species most closely related to humans in the evolutionary tree.

"The similarity in the form and function of the gestures in a human infant, a baby chimpanzee and a baby bonobo was remarkable," said Patricia Greenfield, a Distinguished Professor of Psychology at UCLA and co-author of the study, published in the open-access journal Frontiers in Psychology.

Gestures made by all three species included reaching, pointing with fingers or the head, and raising the arms to ask to be picked up. The researchers called "striking" the finding that the gestures of all three species were "predominantly communicative," Greenfield said.

To be classified as communicative, a gesture had to include eye contact with the conversational partner, be accompanied by vocalization (non-speech sounds) or include a visible behavioral effort to elicit a response. The same standard was used for all three species. For all three, gestures were usually accompanied by one or more behavioral signs of an intention to communicate.

Charles Darwin showed in his 1872 book "The Expression of the Emotions in Man and Animals" that the same facial expressions and basic gestures occur in human populations worldwide, implying that these traits are innate. Greenfield and her colleagues have taken Darwin's conclusions a step further, providing new evidence that the origins of language can be found in gestures and new insights into the co-evolution of gestures and speech.

The apes included in the study were named Panpanzee, a female chimpanzee (Pan troglodytes), and Panbanisha, a female bonobo (Pan paniscus). They were raised together at the Language Research Center in Atlanta, which is co-directed by Sue Savage-Rumbaugh, a co-author of the study. There, the apes learned to communicate with caregivers using gestures, vocalizations and visual symbols (mainly geometric shapes) called lexigrams.

"Lexigrams were learned, as human language is, during meaningful social interactions, not from behavioral training," said the study's lead author, Kristen Gillespie-Lynch, an Assistant Professor of Psychology at the City University of New York and a former UCLA graduate student in Greenfield's laboratory.

The human girl grew up in her parents' home, along with her older brother. Where the apes' symbols were visual, the girl's symbols took the form of spoken words. Video analysis for her began at 11 months of age and continued until she was 18 months old; video analysis for the two apes began at 12 months of age and continued until they were 26 months old. An hour of video was analyzed each month for the girl, the chimpanzee and the bonobo.

Overall, the findings support the "gestures first" theory of the evolution of language. During the first half of the study, communicating with gestures was dominant in all three species. During the second half, all three species increased their symbol production -- words for the child and lexigrams for the apes.

"Gesture appeared to help all three species develop symbolic skills when they were raised in environments rich in language and communication," said Gillespie-Lynch, who conducted the research while she was at UCLA. This pattern, she said, suggests that gesture plays a role in the evolution, as well as the development, of language.

At the beginning stage of communication development, gesture was the primary mode of communication for human infant, baby chimpanzee and baby bonobo. The child progressed much more rapidly in the development of symbols. Words began to dominate her communication in the second half of the study, while the two apes continued to rely predominantly on gesture.

"This was the first indication of a distinctive human pathway to language," Greenfield said.

All three species increased their use of symbols, as opposed to gestures, as they grew older, but this change was far more pronounced for the human child. The child's transition from gesture to symbol could be a developmental model of the evolutionary pathway to human language and thus evidence for the "gestural origins of human language," Greenfield said.

While gesture may be the first step in language evolution, the psychologists also found evidence that the evolutionary pathway from gesture to human language included the "co-evolution of gestural and vocal communication." Most of the child's gestures were accompanied by vocalization (non-language sounds); the apes' gestures rarely were.

"This finding suggests that the ability to combine gesture and vocalization may have been important for the evolution of language," Greenfield said.

The researchers conclude that humans inherited a language of gestures and a latent capacity for learning symbolic language from the last ancestor we share with our chimpanzee and bonobo relatives -- an ancestor that lived approximately 6 million years ago.

The evolution of human language built on capacities that were already present in the common ancestor of the three species, the psychologists report.

"Our cross-species comparison provides insights into the communicative potential of our common ancestor," Gillespie-Lynch said.

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Scientists confirm theory regarding the origins of the sucking disc of remora fish

Scientists confirm theory regarding the origins of the sucking disc of remora fish

The research is published in the Journal of Morphology.

The world's eight species of remoras range from 1 to 3 feet and are primarily found in tropical open-ocean waters. They use their sucking disc to attach themselves to large marine animals and feed off of scraps of food and parasites from the larger animal.

The idea that the sucker disc is developed from the dorsal fin is not new and dates to the early 1800s. Since then, many scientists have suggested it was derived from the dorsal fin but nobody had studied the development of the remora from its earliest larval stages. "One reason I think this hasn't been done before is due to the difficulty in finding early stage remora larvae" said Dave Johnson, zoologist at the Smithsonian's National Museum of Natural History and co-author of the research. "In our study we closely tracked the development of the sucking disc beginning with tiny remora larvae, through to juvenile and adult remoras. We followed the earliest stages of the disc's development by matching the first vestiges of elements of the sucking disc with the first vestiges of elements of the dorsal fins of another fish, the white perch (Morone americana), which has the typical dorsal fin of most fishes."

By doing this, the team was able to identify which of three main fin elements -- the distal radials, the proximal-middle radials, and the fin spines -- are radically modified and develop into the different elements of the remora's unusual disc.

Up to a certain stage in the fish's development, the dorsal fin can be seen developing in the same way and looking very similar in both fishes. Then, through a series of small changes, the remora's dorsal fin begins to expand and shift towards the head. By the time the remora has reached about 30mm in length, the dorsal fin has become a fully formed 2mm sucking disc. It still has the components found in the dorsal fin, the tiny fin spines, spine bases and supporting bones, but the spine bases have greatly expanded.

This research thus confirmed that the sucking disc is formed by a massive expansion of the dorsal fin through small changes while the fish is developing. It is not the result of the evolution of a completely new structure.

Before developing their disc, remora larvae have very distinctive hooked teeth protruding from the lower jaw. "Because remora larvae at this stage are relatively rare in plankton collections, I have often wondered, although we don't have any evidence for it, if maybe remora larvae are not free living in the plankton layer but go into the gill cavities of fishes and use their hooked teeth to hang on until they develop a disc," said Johnson. "Fodder for future research."

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Spooky action put to order: Different types of 'entanglement' classified

Spooky action put to order: Different types of 'entanglement' classified

June 6, 2013 — "I think I can safely say that nobody understands quantum mechanics." Thus spoke the American physicist Richard Feynman -- underlining that even leading scientists struggle to develop an intuitive feeling for quantum mechanics. One reason for this is that quantum phenomena often have no counterpart in classical physics. A typical example is the quantum entanglement: Entangled particles seem to directly influence one another, no matter how widely separated they are. It looks as if the particles can 'communicate' with one another across arbitrary distances. Albert Einstein, famously, called this seemingly paradoxical behaviour "spooky action at a distance."

When more than two particles are entangled, the mutual influence between them can come in different forms. These different manifestations of the entanglement phenomenon are not fully understood, and so far there exists no general method to systematically group entangled states into categories. Reporting in the journal Science, a group of mathematicians and physicists around Matthias Christandl, professor at the Institute for Theoretical Physics, provides an important contribution towards putting the "spooky action" to order. The team has developed a method that allows them to assigning a given quantum state to a class of possible entanglement states. Such a method is important because, among other things, it helps to predict how potentially useful the quantum state can be in technological applications.

Putting entangled states in their place

Together with Brent Doran, a professor in the Department for Mathematics at ETH Zurich, and David Gross, a professor at the University of Freiburg in Germany, Christandl and his PhD student Michael Walter, first author of the Science publication, introduce a method in which different classes of entangled states are associated with geometric objects known as polytopes. These objects represent the "space" that is available to the states of a particular entanglement class. Whether or not a given state belongs to a specific polytope can be determined by making a number of measurements on the individual particles. Importantly, there is no need to measure several particles simultaneously, as is necessary in other methods. The possibility to characterise entangled states through measurements on individual particles makes the new approach efficient, and means also that it can be extended to systems with several particles.

The ability to gain information about entangled states of several particles is a central aspect of this work, explains Christandl: "For three particles, there are two fundamentally different types of entanglement, one of which is generally considered more 'useful' than the other. For four particles, there is already an infinite number of ways to entangle the particles. And with every additional particle, the complexity of this situation gets even more complex." This quickly growing degree of complexity explains why, despite a large number of works that have been written on entangled states, only very few systems with more than a handful of particles have been fully characterized. "Our method of entanglement polytopes helps to tame this complexity by classifying the states into finitely many families," adds Michael Walter.

Quantum technologies on the horizon

Quantum systems with several particles are of interest because they could take an important role in future technologies. In recent years, scientists have proposed, and partly implemented, a wide variety of applications that use quantum-mechanical properties to do things that are outright impossible in the framework of classical physics. These applications range from the tap-proof transmission of messages, to efficient algorithms for solving computational problems, to tech-niques that improve the resolution of photolithographic methods. In these applications, entangled states are an essential resource, precisely because they embody a fundamental quantum-mechanical phenomenon with no counterpart in classical physics. When suitably used, these complex states can open up avenues to novel applications.

A perfect match

The link between quantum mechanical states and geometric shapes has something to offer not only to physicists, but also to mathematicians. According to Doran, the mathematical methods that have been developed for this project may be exploited in other areas of mathematics and physics, but also in theoretical computer science. "It usually makes pure mathematicians a bit uncomfortable if someone with an 'applied' problem wants to hit it with fancy mathematical machinery, because the fit of theory to problem is rarely good," says Doran. "Here it is perfect. The potential for long-term mutually beneficial feedback between pure mathematicians and quantum information theory and experiment is quite substantial."

The method of entanglement polytopes, however, is more than just an elegant mathematical construct. The researchers have shown in their calculations that the technique should work reliably under realistic experimental conditions, signalling that the new method can be used directly in those systems in which the novel quantum technologies are to be implemented. And such practical applications might eventually help to gain a better understand of quantum mechanics.

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Conflict-of-interest restrictions needed to ensure strong FDA review

Conflict-of-interest restrictions needed to ensure strong FDA review

The 2012 legislation removed measures put in place by an earlier law passed in 2007, according to the report by Susan F. Wood, PhD, an associate professor of health policy at SPHHS and Jillian K. Mador, a medical student at the GW School of Medicine & Health Sciences (SMHS). The 2007 FDA Amendments Act put caps on the number of experts with conflict of interest who could serve on FDA advisory panels in order to ensure an impartial review of new drugs, the authors said.

They say there is good reason to worry about the revisions in the law that now allow FDA panels to have more members who report a conflict -- such as consulting fees from drug companies. The removal of the requirement for "caps" on advisory committee members with financial conflicts was seen as a top priority of the pharmaceutical industry during the 2012 passage of the FDA Safety and Innovation Act.

"Panels top-heavy with experts who have financial ties to industry might be more likely to dismiss or ignore scientific evidence of risks or other problems," said Wood, who is a former FDA official and the lead author on the paper. "This analysis also suggests that loosening the restrictions could lead to an appearance of conflict -- and to potentially biased recommendations for approval or disapproval of a FDA regulated product."

The authors point to historical examples of cases in which loaded panels voted for drugs that were later found to have serious safety problems.

The 2012 law was passed after the drug industry complained that the conflict of interest restrictions slowed down the FDA approval process and made it hard to fill panel positions with qualified experts. But Wood and Mador looked at the evidence and concluded that there are plenty of scientists with expertise to fill these positions -- without the ties to the industry.

The analysis goes on to say that the restrictions did not affect FDA's productivity in the past and there is little reason to think that reinstituting the caps would slow down the process of bringing safe new drugs to market today. The analysis also demonstrates that the caps have never been reached, so FDA had apparently been successful in identifying experts without financial conflicts.

The analysis concludes that the evidence does not support the decision to remove the caps on conflict of interest and points out that Congress will soon begin discussing reauthorization of the 2012 law which is revised every five years. The authors urge the scientific and medical community to weigh in early on those discussions in order to point out concerns -- and to ensure that the FDA Advisory Committee and review process remains strong and effective.

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